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KMID : 0367419940370010122
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Journal of Korean Pediatric Society
1994 Volume.37 No. 1 p.122 ~ p.128
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Two Cases of Pseudohypoaldosteronism Type I
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Abstract
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Pseudohypoaldosteronism type 1 is a genetic renal tubular disease of salt wasting, presenting in young infants. Tubular unresponsiveness to elevated endogenous and exogenous aldosterone is the suggested pathogenetic mechanism. Oral sodium
chloride
supplementation relieve the clinical symptoms and electrolyte distrubances.
We experienced 2 cases of PHA type 1 in 38-day and 45-day old male infants who were presented with failure to thrive, vomiting and/or dehydration. Laboratory data showed hyponatremia, hyperkalemia, hypochloremia and metabolic acidosis. Renal and
adrenal
functions were normal. Plasma renin activity and plasma aldosterone concentration were markedly elevated. Under the diagnosis of pseudohypoaldosteronism type 1, oral supplementation of NaCl and/or kayexalate improved the clinical states of the
patients.
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KEYWORD
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